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Novel, Nonpeptidic Cyanamides as Potent and Reversible Inhibitors of Human Cathepsins K and L

✍ Scribed by Falgueyret, Jean-Pierre; Oballa, Renata M.; Okamoto, Osamu; Wesolowski, Gregg; Aubin, Yves; Rydzewski, Robert M.; Prasit, Peppi; Riendeau, Denis; Rodan, Sevgi B.; Percival, M. David


Book ID
121013162
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
197 KB
Volume
44
Category
Article
ISSN
0022-2623

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Novel Peptidyl Aryl Vinyl Sulfones as Hi
✍ Laura Mendieta; Anna PicΓ³; Teresa TarragΓ³; Meritxell TeixidΓ³; Marcos Castillo; L πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 995 KB

## Abstract __Herein we present the design, synthesis, and evaluation of a structurally novel library of 20 peptidyl 3‐aryl vinyl sulfones as inhibitors of cathepsinsβ€…L and B. The building blocks, described here for the first time, were synthesized in a highly efficient and enantioselective manner,