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Novel Nitrofurazone Derivatives Endowed with Antimicrobial Activity

✍ Scribed by Dalci J. Brondani; Nelly Caetano; Diogo R. de M. Moreira; Rogério R. Soares; Vânia T. Lima; Janete M. de Araújo; Fabiane C. de Abreu; Boaz G. de Oliveira; Marcelo Z. Hernandes; Ana C. L. Leite

Book ID
101639516
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
264 KB
Volume
341
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

The N‐alkylated derivatives from nitrofurazone were synthesised and evaluated in vitro for their efficacy as antimicrobial agents against representative strains, including methicillin‐resistant Staphylococcus aureus (MRSA). The derivative 2a demonstrated greater activity than the prototype and was comparable to currently used antimicrobial drugs.

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