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Novel mutations in IRF6 in nonsyndromic cleft lip with or without cleft palate: When should IRF6 mutational screening be done?

✍ Scribed by Fernanda Sarquis Jehee; Beatriz A. Burin; Kátia M. Rocha; Roseli Zechi-Ceide; Daniela F. Bueno; Luciano Brito; Josiane Souza; Gabriela Ferraz Leal; Antonio Richieri-Costa; Nivaldo Alonso; Paulo A. Otto; Maria Rita Passos-Bueno


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
134 KB
Volume
149A
Category
Article
ISSN
1552-4825

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Genetic risk factors for nonsyndromic cl
✍ Augusto Rojas-Martinez; Heiko Reutter; Oscar Chacon-Camacho; Rafael B. R. Leon-C 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 68 KB 👁 2 views

## Abstract **INTRODUCTION:** Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common of all birth defects. NSCL/P has a multifactorial etiology that includes both genetic and environmental factors. The __IRF6__ gene and three further susceptibility loci at 8q24, 10q2