Novel molecular screening approaches in colorectal cancer
โ Scribed by Seth Miller; Scott Steele
- Book ID
- 112135812
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 211 KB
- Volume
- 105
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract ## Background Mass screening for colorectal cancer reduces mortality and, with recent advances in molecular genetics, molecular stool-based tests have produced promising results. This article reviews this innovation and discusses its clinical significance. ## Methods Medline searches
Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease, caused by germline mutations in DNA mismatch-repair genes (MMR). These mutations lead to microsatellite instability (MSI). It has been found that the MSI is not confined to the setting of hereditary disease and may