Because clearance of hepatitis B virus (HBV) infection is rarely, if ever, achievable, the goals of therapy necessarily focus on prevention of bad clinical outcomes. Ideally, therapies would be shown to prevent tangible clinical endpoints like development of cirrhosis, end-stage liver disease and he
Novel molecular approaches toward therapy of chronic hepatitis B
β Scribed by M. Nassal
- Publisher
- Springer Vienna
- Year
- 1997
- Tongue
- English
- Weight
- 502 KB
- Volume
- 142
- Category
- Article
- ISSN
- 1432-8798
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## Abstract Virological data on chronic hepatitis B virus (HBV) infection in Greece are limited. HBV genotypes, surface antigen (HBsAg) subtypes, and HBsAg βaβ determinant mutations among patients infected chronically with HBV, were investigated. Serum samples from 135 HBsAg positive patients were
## SUMMARY Hepatitis B virus is considered one of the most significant environmental carcinogens in humans. Because the mechanisms of HBV replication and the development of hepatocellular carcinoma (HCC) are partially known, HBVβassociated pathogenesis remains a challenge to increase its understand
Eight patients with chronic hepatitis B entered a pilot study of gamma interferon and alpha interferon in combination. Gamma interferon alone had minimal inhibitory effects on serum levels of hepatitis B virus as monitored by serum HBV DNA and DNA-polymerase activity. The drug also gave troublesome