Novel marine sponge derived amino acids 7. The fenestins

✍ Scribed by Siraj Omar; Laura Tenenbaum; Lawrence V. Manes; Phillip Crews

• Book ID: 104216818
• Publisher: Elsevier Science
• Year: 1988
• Tongue: French
• Weight: 268 KB
• Volume: 29
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)80794-7

✦ Synopsis

Cyclic peptides, fenestins A (l), B (2) and a known diketopiperazine, cycle-(L-Pro-I.,-Val) (3) are reported from the sponge Leuconhloeus fenestrata. Fenestins A and B are respectively cycle-(L-Pro-L-Pro-L-Leu-L-Ile) and cycle-(L-Pro-L-Val-L-Pro-L-Leu-L-Ile). A majority of the amino acids isolated from marine sponges seemingly arise from tyrosine or tryptophan biosynthesis'. Examples are respectively psammaplin A from Psammaplysilla sp.2 and 5-bromo-N,N-dimethyltryptamine from Smenospongia sp.. 3a Much of the other sponge amino acid chemistry falls into three categories: simple derivatives, such as the dysidenin dipeptides from Dvsidea herbacea 3b, the cyclic dipeptides from Tedania 'On leave from the National University of Malaysia (Sabah)