Novel hyperbranched polyethyleneimine conjugate as an efficient non-viral gene delivery vector
β Scribed by Tae-Hun Kim, Hye Choi, Gwang Sig Yu, Jeil Lee, Joon Sig Choi
- Book ID
- 120717229
- Publisher
- The Polymer Society of Korea
- Year
- 2013
- Tongue
- English
- Weight
- 734 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1598-5032
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π SIMILAR VOLUMES
## Abstract ## Background Nonβviral methods of gene delivery have been an attractive alternative to virusβbased gene therapy. However, the vectors that are currently available have drawbacks limiting their therapeutic application. ## Methods We have developed a selfβassembled nonβviral gene carr
Cholesterol-conjugated H 5 R 10 and H 10 R 10 oligopeptides (HR15-Chol and HR20-Chol) were designed and synthesized. These amphiphilic oligopeptides were able to self-assemble into cationic micelles in aqueous solution at low concentrations, and their critical micelle concentrations in sodium acetat