Novel Gemini analogs of 1α,25-dihydroxyvitamin D3 with enhanced transcriptional activity
✍ Scribed by Franci A Weyts; Puneet Dhawan; Xiaoyu Zhang; June E Bishop; Milan R Uskokovic; Yan Ji; George P Studzinski; Anthony W Norman; Sylvia Christakos
- Book ID
- 113487047
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 312 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0006-2952
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A series of analogs of 1 alpha,25-dihydroxyvitamin D3[1,25(OH)2D3] with alkyl substitutions in 26- and 27-positions were tested for calcium (Ca) regulating activity. The potencies of dialkyl analogs in stimulating bone resorption in neonatal mouse calvaria cultures were the highest in 1 alpha,25-dih
## Abstract The active form of vitamin D~3~, 1,25(OH)~2~D~3~, is known, besides its classical effects on calcium and bone, for its pronounced immunomodulatory effects that are exerted both on the antigen‐presenting cell level as well as directly on the T lymphocyte level. In animal models, these im
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