## Abstract The active form of vitamin D~3~, 1,25(OH)~2~D~3~, is known, besides its classical effects on calcium and bone, for its pronounced immunomodulatory effects that are exerted both on the antigen‐presenting cell level as well as directly on the T lymphocyte level. In animal models, these im
Analogs of 1α,25-dihydroxyvitamin D3 as novel inhibitors of renin biosynthesis
✍ Scribed by Guilin Qiao; Juan Kong; Milan Uskokovic; Yan Chun Li
- Book ID
- 116697590
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 378 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0960-0760
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## Abstract For Abstract see ChemInform Abstract in Full Text.
In this communication we describe the synthesis of \(1 \alpha, 25\)-dihydroxyvitamin \(\mathrm{D}_{3}\) - \(3 \beta\)-bromoacetate \(\left[1,25(\mathrm{OH})_{2}-\mathrm{BE}\right]\), an analog of \(1 \alpha, 25\)-dihydroxyvitamin \(\mathrm{D}_{3}\left[1,25(\mathrm{OH})_{2} \mathrm{D}_{3}\right]\), a
A series of analogs of 1 alpha,25-dihydroxyvitamin D3[1,25(OH)2D3] with alkyl substitutions in 26- and 27-positions were tested for calcium (Ca) regulating activity. The potencies of dialkyl analogs in stimulating bone resorption in neonatal mouse calvaria cultures were the highest in 1 alpha,25-dih