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Novel FLT3 point mutations within exon 14 found in patients with acute myeloid leukaemia

✍ Scribed by Derek L. Stirewalt; Soheil Meshinchi; Steven J. Kussick; Kayla M. Sheets; Era Pogosova-Agadjanyan; Cheryl L. Willman; Jerald P. Radich


Book ID
108672502
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
130 KB
Volume
124
Category
Article
ISSN
0007-1048

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Mutations affecting NPM, FLT3 ITD and TKD were present in 25% (30/120), 22% (26/120) and 8/120 (7%), respectively. NPM mutations were most prevalent in patients with normal karyotype (24/52; 46%) and were associated with FLT3-ITD mutations (16/26; 62%). Regarding the prognostic significance of NPM a