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Novel families of vacuolar amino acid transporters

✍ Scribed by Takayuki Sekito; Yuki Fujiki; Yoshinori Ohsumi; Yoshimi Kakinuma

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 121 KB
Volume: 60
Category: Article
ISSN: 1521-6543
DOI: 10.1002/iub.92

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Amino acids are compartmentalized in the vacuoles of microorganisms and plants. In Saccharomyces cerevisiae, basic amino acids accumulate preferentially into vacuoles but acidic amino acids are almost excluded from them. This indicates that selective machineries operate at the vacuolar membrane. The members of the amino acid/auxin permease family and the major facilitator superfamily involved in the vacuolar compartmentalization of amino acids have been recently identified in studies using S. cerevisiae. Homologous genes for these transporters are also found in plant and mammalian genomes. The physiological significance in response to nitrogen starvation can now be discussed. © 2008 IUBMB IUBMB Life, 60(8): 519–525, 2008

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