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Role of glial amino acid transporters in synaptic transmission and brain energetics

✍ Scribed by Païkan Marcaggi; David Attwell

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
164 KB
Volume
47
Category
Article
ISSN
0894-1491

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✦ Synopsis

Abstract

This article reviews how the uptake of neurotransmitter by glial amino acid transporters limits the spatial spread of transmitter to preserve the independent operation of nearby synapses, temporally shapes postsynaptic currents, and regulates the effects of tonic transmitter release. We demonstrate the importance of amino acid uptake and recycling mechanisms for preventing the loss of energetically costly neurotransmitter from the brain, and also examine the suggestion that glutamate uptake into glia plays a key role in regulating the energy production of the brain. Finally, we assess the role of glial amino acid transporters in transmitter recycling pathways. © 2004 Wiley‐Liss, Inc.

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