✦ LIBER ✦

Novel DNA polymorphism in the mouse tumor necrosis factor receptors type 1 and type 2

✍ Scribed by Shintaro Takao; Kirk Mykytyn; Chaim O. Jacob

Book ID: 104657766
Publisher: Springer-Verlag
Year: 1993
Tongue: English
Weight: 433 KB
Volume: 37
Category: Article
ISSN: 0093-7711
DOI: 10.1007/bf00191885

No coin nor oath required. For personal study only.

✦ Synopsis

The introduction of the polymerase chain reaction (PCR) provides an entirely new means of analyzing DNA polymorphism and makes practical the analysis of length variation in simple-sequence tandem repeats of dinucleotides. In the process of cloning and sequencing the mouse genomic DNA for tumor necrosis factor (TNF) receptors type 1 and type 2, we identified two simple dinucleotide repeats within the noncoding regions of TNF receptor type 1 and three such sequences within TNF receptor type 2. PCR analysis of these sequences, using genomic DNA from 21 different inbred and wild mouse strains, as demonstrated by running the amplified products on sequencing gels, showed that the repeats are highly polymorphic. We identified seven alleles of TNF receptor type 2 and five alleles of TNF receptor type 1. Using these polymorphic markers in two sets of recombinant inbred strains of mice, the chromosomal localization of Tnfr-1 was mapped to mouse chromosome 6 and Tnfr-2 was located to the distal portion of mouse chromosome 4.

📜 SIMILAR VOLUMES

Analysis of liver regeneration in mice l

Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: Requirement for type 1 but not type 2 receptor

✍ Yasuhiro Yamada; Eric M. Webber; Irina Kirillova; Jacques J. Peschon; Nelson Fau 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 962 KB

We used KO mice lacking either TNF receptor 1 (TNFR-1) or receptor 2 (TNFR-2) to determine whether signaling at the start of liver regeneration after partial hepatectomy (PH) involves only one or both TNF receptors and to analyze in more detail the abnormalities caused by lack of TNFR-1 receptor, wh

The tumor necrosis factor type 2 recepto

The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-α-induced bone resorption lacunae on mouse calvariae

✍ Kenichi Nagano; Neil Alles; Anower Hussain Mian; Asako Shimoda; Nobuyuki Morimot 📂 Article 📅 2011 🏛 Springer 🌐 English ⚖ 596 KB

Polymorphisms of the tumor necrosis fact

Polymorphisms of the tumor necrosis factor receptor type 1 locus among autoimmune susceptible and resistant inbred rat strains

✍ Takefumi Furuya; Jennifer L. Salstrom; Bina Joe; Akira Hashiramoto; David E. Dob 📂 Article 📅 2001 🏛 Springer-Verlag 🌐 English ⚖ 40 KB

A novel mutation of tumor necrosis facto

A novel mutation of tumor necrosis factor receptor alpha type 1 associated with TRAPS and amyloidosis

✍ Broeders, E. Nilufer ;Abramowicz, Daniel ;Abramowicz, Marc J. ;Parma, Jasmine 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 30 KB 👁 1 views

Imbalance between soluble tumour necrosi

Imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis

✍ Ikuyo Ikezawa; Hideaki Tai; Yasuko Shimada; Yasutaka Komatsu; Johnah C. Galicia; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB

Moxibustion treatment restoring the inte

Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn’s disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2

✍ Yin Shi; En-hua Zhou; Huan-gan Wu; Ci-li Zhou; Qian-yao Wang; Li Qi 📂 Article 📅 2011 🏛 Chinese Association of Traditional and Western Med 🌐 English ⚖ 696 KB