Novel Cytostatic Lanostanoid Triterpenes from Ganoderma australe

✍ Scribed by Francisco León; Meiser Valencia; Augusto Rivera; Ivonne Nieto; José Quintana; Francisco Estévez; Jaime Bermejo

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: German
• Weight: 123 KB
• Volume: 86
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200390251

✦ Synopsis

Abstract

Two new compounds 1 and 2, together with the known sterols ergosterol, 5,6‐dehydroergosterol, and ergosterol peroxide, and four polyoxygenated lanostanoid triterpenes named applanoxidic acid A (3), C (4), F (5), and G (6) were isolated from the fungus Ganoderma australe. The structures of the new compounds were elucidated by means of spectroscopic techniques, while the known triterpenoids 3–6 were identified by comparing their spectral data with those reported in the literature. Compounds 1–6 inhibited the viability and growth of the HL‐60 cell line.