Novel conopeptides in a form of disulfide-crosslinked dimer
β Scribed by Xue-Chen Wu; Mi Zhou; Can Peng; Xiao-Xia Shao; Zhan-Yun Guo; Cheng-Wu Chi
- Book ID
- 116832159
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 847 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0196-9781
No coin nor oath required. For personal study only.
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## Abstract Conotoxins exhibit a high degree of selectivity and potency for a range of pharmacologically relevant targets. The rapid access to libraries of conotoxin analogues, containing multiple intramolecular disulfide bridges for use in drug development, can be a very labor intensive, multiβste
671 for the classification of patterns of the three-dimensional folding of a covalently crosslinked polypeptide chain has been extended to nonplanar proteins. The procedure described earlier was applicable only to proteins termed planar, i.e., with a connexity of the crosslinks (e.g., disulfide bond