Spatial geometric arrangements of disulfide-crosslinked loops in nonplanar proteins
✍ Scribed by Takeshi Kikuchi; George Némethy; Harold A. Scheraga
- Book ID
- 102878373
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 717 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0192-8651
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✦ Synopsis
671 for the classification of patterns of the three-dimensional folding of a covalently crosslinked polypeptide chain has been extended to nonplanar proteins. The procedure described earlier was applicable only to proteins termed planar, i.e., with a connexity of the crosslinks (e.g., disulfide bonds) that can be represented in a planar diagram. The procedure described in the present work is applicable to any (planar or nonplanar) pattern of crosslinking. The classification is based on a systematic and objective method of enumeration of spatial geometric arrangements of loops (SGAL) using no information other than the location of the disulfide bonds in the amino acid sequence. Various SGAL classes correspond to the presence of different ways of mutual penetration of loops, called thrustings and entanglements. Information on SGAL classes can be of use in structural predictions of folding patterns of proteins.