𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Novel cholic acid functionalized star oligo/poly(DL-lactide)s for biomedical applications

✍ Scribed by Tao Zou; Si-Xue Cheng; Xian-Zheng Zhang; Ren-Xi Zhuo

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
285 KB
Volume
82B
Category
Article
ISSN
1552-4973

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Novel cholic acid functionalized star oligo/poly(DL‐lactide)s with different molecular weights were synthesized through the ring‐opening polymerization of DL‐lactide initiated by cholic acid. Compared with poly(DL‐lactide), these star oligo/poly(DL‐lactide)s show faster hydrolytic degradation rates, and the degradation mechanism changes from bulk erosion to surface erosion with decreasing molecular weight. Based on the specific physicochemical properties of the novel star oligo/poly(DL‐lactide), the drug delivery system with submicron size was fabricated using a very convenient “ultrasonic dispersion method” which did not involve toxic organic solvents. The in vitro drug release was studied. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007

📜 SIMILAR VOLUMES

Synthesis of novel cholic acid functiona
Synthesis of novel cholic acid functionalized branched oligo/poly(ε-caprolactone)s for biomedical applications
✍ Hui-Li Fu; Lan Yu; Hua Zhang; Xian-Zheng Zhang; Si-Xue Cheng; Ren-Xi Zhuo 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 401 KB

## Abstract Novel cholic acid functionalized branched oligo/poly(ε‐caprolactone)s were synthesized through the ring‐opening polymerization of ε‐caprolactone initiated by cholic acid with hydroxyl groups. The molecular weight of the branched polymers can be adjusted by controlling the feed ratio of

A simple synthetic route to the formatio
A simple synthetic route to the formation of a block copolymer of poly(lactic-co-glycolic acid) and polylysine for the fabrication of functionalized, degradable structures for biomedical applications
✍ Lavik, Erin B. ;Hrkach, Jeffrey S. ;Lotan, Noah ;Nazarov, Rina ;Langer, Robert 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 65 KB 👁 2 views

This article documents the formation of a block copolymer of poly(lactic-co-glycolic acid) and polylysine via a simple coupling technique using dicyclohexyl carbodiimide (DCC). The resulting polymer has been characterized via UV-Vis spectroscopy, GPC, (1)H NMR, and elemental analysis, is soluble in