✦ LIBER ✦

A simple synthetic route to the formation of a block copolymer of poly(lactic-co-glycolic acid) and polylysine for the fabrication of functionalized, degradable structures for biomedical applications

✍ Scribed by Lavik, Erin B. ;Hrkach, Jeffrey S. ;Lotan, Noah ;Nazarov, Rina ;Langer, Robert

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 65 KB
Volume: 58
Category: Article
ISSN: 0021-9304
DOI: 10.1002/1097-4636(2001)58:3<291::aid-jbm1019>3.0.co;2-n

No coin nor oath required. For personal study only.

✦ Synopsis

This article documents the formation of a block copolymer of poly(lactic-co-glycolic acid) and polylysine via a simple coupling technique using dicyclohexyl carbodiimide (DCC). The resulting polymer has been characterized via UV-Vis spectroscopy, GPC, (1)H NMR, and elemental analysis, is soluble in a wide variety of solvents, and is easily processable, making the technique a simple and practical one for the formation of functionalized, degradable block copolymers for the fabrication of functionalized structures for biomedical applications.