𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Novel Chemistry of α-Tosyloxy Ketones: Applications to the Solution- and Solid-Phase Synthesis of Privileged Heterocycle and Enediyne Libraries

✍ Scribed by Nicolaou, K. C.; Montagnon, T.; Ulven, T.; Baran, P. S.; Zhong, Y.-L.; Sarabia, F.


Book ID
119941431
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
198 KB
Volume
124
Category
Article
ISSN
0002-7863

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Solid and solution phase synthesis of α-
✍ Seock-Kyu Khim; John M. Nuss 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 276 KB

3,3-Diethoxy-N-sulfonyl and carbamoyl azetidin-2-ones undergo efficient ring-opening reaction with various amine nucleophiles. Subsequent acid hydrolysis of the ketal moiety generated 0t-keto amides in excellent overall yields. The naturally occurring serine protease inhibitor poststatin was synthes