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Novel biosynthetic routes to non-proteinogenic amino acids as chiral pharmaceutical intermediates

✍ Scribed by David J Ager; Tao Li; David P Pantaleone; Richard F Senkpeil; Paul P Taylor; Ian G Fotheringham

Book ID: 114395453
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 152 KB
Volume: 11
Category: Article
ISSN: 1381-1177
DOI: 10.1016/s1381-1177(00)00055-2

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## Abstract The diastereoselective synthesis of the sterically hindered, __γ__‐branched __α__‐amino acid derivative (2__S__,4__S__)‐**24a** and its __N__‐[(__tert__‐butoxy)carbonyl](Boc)‐protected alcohol (2__S__,4__S__)‐**19**, both key intermediates of a novel class of nonpeptide renin inhibitors