The Nonchiral Bislactim Diethoxy Ether as a Highly Stereo-Inducing Synthon for Sterically Hindered, γ-Branched α-Amino Acids: A Practical, Large-Scale Route to an Intermediate of the Novel Renin Inhibitor Aliskiren.

The Nonchiral Bislactim Diethoxy Ether a

The Nonchiral Bislactim Diethoxy Ether as a Highly Stereo-Inducing Synthon for Sterically Hindered, γ-Branched α-Amino Acids: A Practical, Large-Scale Route to an Intermediate of the Novel Renin Inhibitor Aliskiren

✍ Richard Göschke; Stefan Stutz; Walter Heinzelmann; Jürgen Maibaum 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 German ⚖ 327 KB

## Abstract The diastereoselective synthesis of the sterically hindered, __γ__‐branched __α__‐amino acid derivative (2__S__,4__S__)‐**24a** and its __N__‐[(__tert__‐butoxy)carbonyl](Boc)‐protected alcohol (2__S__,4__S__)‐**19**, both key intermediates of a novel class of nonpeptide renin inhibitors