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Novel Approach for the Synthesis of Five-Membered-Ring-Fused Pyrazinones

✍ Scribed by Vincent Gembus; Solenn Janvier; Jean-Pierre Lecouvé; Philippe Gloanec; Francis Marsais; Vincent Levacher

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 114 KB
Volume: 2010
Category: Article
ISSN: 1434-193X
DOI: 10.1002/ejoc.201000435

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✦ Synopsis

Abstract

We describe a new route to access important pharmaceutical intermediates for the synthesis of constrained fused pyrazinones. These compounds are prepared in five to seven steps with a good overall yield from glycine methyl ester and commercial propanediol derivatives involving an intramolecular alkylation of a glycine moiety as key step.

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