𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Novel approach for the conversion of natural Δ3 cephalosporin derivatives into corresponding Δ2 cephalosporin derivatives

✍ Scribed by Korrapati. V. V. Prasada Rao; Ramesh Dandala; Vija Y. K. Handa; Anand. G. Kamat; Inti. V. Subramanyeswara Rao; Ananta Rani; Andra Naidu

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
211 KB
Volume
44
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

magnified image

A simple one pot synthetic method for the isomerization of cephem double bond from the natural 3‐position to 2‐cephem positions is affected by silylation. Thus cephalosporin acids are treated with Ntrimethylsilylacetamide (MSA) or N,O‐bis(trimethylsilyl)acetamide (BSA) and the resulting silyl esters are treated with triethylamine at ambient temperature in the same pot to afford Δ^2^‐cephalosporins, which are potentially related compounds in cephalosporin antibacterial compounds.

📜 SIMILAR VOLUMES

ChemInform Abstract: Novel Approach for
ChemInform Abstract: Novel Approach for the Conversion of Natural Δ3 Cephalosporin Derivatives into Corresponding Δ2 Cephalosporin Derivatives
✍ Korrapati V. V. Rao; Ramesh Dandala; Vijay K. Handa; Anand. G. Kamat; Inti. V. S 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 26 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v