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Novel applications of the modified polonovski reaction - VII preparation of isoquinuclidines

✍ Scribed by Mauri Lounasmaa; Reija Jokela; Tarja Tamminen (née Ranta)


Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
114 KB
Volume
26
Category
Article
ISSN
0040-4039

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✦ Synopsis


The first successful preparations of the biochemically important isoquinuclidine ring system by the modified Polonovski reaction are described.

A vexing problem in the Iboga alkaloid series (e.g. coronaridine 1) has been the prepara---


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✍ Mauri Lounasmaa; Esko Karvinen; Ari Koskinen; Reija Jokela 📂 Article 📅 1987 🏛 Elsevier Science 🌐 French ⚖ 832 KB

mtract -A practical synthetic entry to Renkert's enamine 1 employing the modified Polonovski reaction is described. Complete "C NUR sprctral data of 1 ia presented. Conformational analysis of the intermediate 1-hydroxy-and l-ethyl-1-hydroxy-indoloquinolizidines 206, 2pB, u and m based on simple but