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Novel Antiviral Therapy Based on Innate Immunity

✍ Scribed by Rico, Tace; Green, Jeremy; Kirsner, Robert S.


Book ID
109875473
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
701 KB
Volume
129
Category
Article
ISSN
0022-202X

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## Abstract Recombinant adenovirus serotype 5 (Ad5) vectors have been studied extensively in preclinical gene therapy models and in a range of clinical trials. However, innate immune responses to adenovirus vectors limit effectiveness of Ad5 based therapies. Moreover, extensive pre‐existing Ad5 imm