Novel antithrombotic agents and the risk of bleeding
โ Scribed by Jan Van Der Linden
- Book ID
- 109143953
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 55 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0372-1248
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract In this review we discuss the limited efficacy for current pharmacological agents used in prophylaxis and treatment of thrombosis and highlight targeted delivery of antiโthrombotic agents to fibrin, platelets, red blood cells and endothelium. ยฉ 2011 IUBMB IUBMB Life, 2011
Derivatization of the octadecathymidylate derivative 18 (T18 ODN) containing a free amine function with sulfo-SIAB@ gave the corresponding iodoacetyl ODN 21. Conjugation of the latter with the thiol-containing pentasaccharide 17c gave pentasaccharide-ODN conjugate 111, which exhibited anti-Xa and an