The utility of combining the vascular targeting agents 5,6-dimethyl-xanthenone-4 acetic acid (DMXAA) and combretastatin A-4 disodium phosphate (CA4DP) with the anticancer drugs cisplatin and cyclophosphamide (CP) was evaluated in experimental rodent (KHT sarcoma), human breast (SKBR3) and ovarian (O
Vascular targeting of antithrombotic agents
β Scribed by Ronald Carnemolla; Vladimir R. Muzykantov
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 275 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1521-6543
- DOI
- 10.1002/iub.474
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
In this review we discuss the limited efficacy for current pharmacological agents used in prophylaxis and treatment of thrombosis and highlight targeted delivery of antiβthrombotic agents to fibrin, platelets, red blood cells and endothelium. Β© 2011 IUBMB IUBMB Life, 2011
π SIMILAR VOLUMES
## Abstract Several technical advances over the years have allowed microsurgery to be successful. However, thrombosis, particularly at the anastomosis site, remains a complication of microvascular surgery. Various preventive measures, including drugs, have been used to improve microvascular surgica
## Abstract ## BACKGROUND Tumor endothelium represents a valuable target for cancer therapy. The vasculature plays a critical role in the survival and continued growth of solid tumor masses; in addition, the inherent differences between tumor blood vessels and blood vessels associated with normal