Novel and efficient synthesis of 4-sulfonyl-2-pyridones

✍ Scribed by Martha L. Minich; Isa D. Watson; Kevin J. Filipski; Jeffrey A. Pfefferkorn

• Book ID: 104096326
• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 944 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.02.120

✦ Synopsis

Heterocyclic 4-sulfonyl-2-pyridones represent useful scaffolds for drug discovery and are also versatile synthetic building blocks. Herein we describe a novel and efficient synthesis of this heterocyclic ring system utilizing an acid mediated cyclo-condensation reaction. This synthetic method affords convenient access to structurally diverse N-substituted 4-sulfonyl-2-pyridones in moderate to good yields.