Novel and Efficient Route for the Synthesis of 4-Aryl-Substituted 2(5H)-Furanones
✍ Scribed by Desai, Jigar; Thombare, Pravin; Argade, Anil; Gite, Sanjay; Shah, Kiran; Pavase, Laxmikant; Patel, Pankaj
- Book ID
- 115317268
- Publisher
- Taylor and Francis Group
- Year
- 2009
- Tongue
- English
- Weight
- 110 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0039-7911
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## Abstract 3,4‐Dichloro‐2(5__H__)‐furanone, which has been prepared efficiently from mucochloric acid, has been transformed selectively into 4‐aryl‐3‐chloro‐2(5__H__)‐furanones either by Suzuki‐ or Stille‐type reactions. These monochloro derivatives have been used as precursors either to (__Z__)‐4
## Abstract Highly optically active 4‐substituted‐2(5__H__)‐furanones 6a‐6j were obtained in good yields with __de__⩾98% by the tandem Michael addition/elimination reaction of chiral 3‐bromo‐2(5__H__)‐furanone (4a), which was conveniently prepared starting from 2‐furaldehyde under mild conditions.