Novel, Achiral 1,3,4-Benzotriazepine Analogues of 1,4-Benzodiazepine-Based CCK 2 Antagonists That Display High Selectivity over CCK 1 Receptors
✍ Scribed by McDonald, Iain M.; Austin, Carol; Buck, Ildiko M.; Dunstone, David J.; Griffin, Eric; Harper, Elaine A.; Hull, Robert A. D.; Kalindjian, S. Barret; Linney, Ian D.; Low, Caroline M. R.; Pether, Michael J.; Spencer, John; Wright, Paul T.; Adatia, Trushar; Bashall, Alan
- Book ID
- 127100418
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 150 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Two benzodiazepine CCK antagonists __N__‐(2,3‐dihydro‐1‐[^14^C]methyl‐2‐oxo‐5‐phenyl‐1H 1,4‐benzodiazepin‐3‐yl)‐benzamide **2** and __N__‐(2,3‐dihydro‐1‐[^14^C]methyl‐2‐oxo‐5‐phenyl‐1H‐1,4‐benzodiazepin‐3‐yl)‐[^14^C]methyl‐benzamide **3** were synthesized in high yields through the reac
We describe the design, synthesis, and structure-activity relationships of triazolobenzodiazepinone CCK1 receptor agonists. Analogs in this series demonstrate potent agonist activity as measured by in vitro and in vivo assays for CCK1 agonism. Our efforts resulted in the identification of compound 4