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Novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors

✍ Scribed by Baker Jawabrah Al-Hourani; Sai Kiran Sharma; Mavanur Suresh; Frank Wuest


Book ID
113496648
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
239 KB
Volume
22
Category
Article
ISSN
0960-894X

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Novel regioselective N-alkylations of 5-
✍ Marija Prhavc; JozΛ‡e Kobe πŸ“‚ Article πŸ“… 1990 πŸ› Elsevier Science 🌐 French βš– 178 KB

Regioselective alkylation of 5-substituted-2H-tetrazoles 1 to 2-alkyl derivatives 3 was achieved via decarboxylative alkylation with alkyl cyanoformates. Lesser selectivity was observed with chloroformates.