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Novel 2-Arylbenzofuran Derivatives from Artocarpus petelotii

✍ Scribed by Lei Chen; Wei Jiang; Ai-Jun Hou


Publisher
John Wiley and Sons
Year
2006
Tongue
German
Weight
132 KB
Volume
89
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

Further phytochemical investigations on the root barks of Artocarpus petelotii Gagnep afforded four novel isoprenylated 2‐arylbenzofuran derivatives, namely artopetelins D–G (1–4). Their structures were elucidated by spectroscopic methods, mainly by 2D‐NMR techniques. The biogenetic origins of artopetelins F and G (3 and 4) were also postulated.


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The structures were elucidated by spectroscopic methods. Norartocarpin (3), cudraflavone C (5), brosimone I (8), artotonkin (11), albanin A (13), and artopetelin M ( 14) showed inhibitory effects on pancreatic lipase with IC 50 values ranging from 1.8 AE 0.1 to 63.8 AE 3.6 mm.