✍ Scribed by Guillaume Castel; Noël Tordo
No coin nor oath required. For personal study only.
Antiviral research is a recent discipline and the number of molecules available to fight against viral infections remains still insufficient. However, both diseases caused by emerging endemic viruses and the existence of resistance from some viruses against antiviral make necessary a constant search for new antiviral drugs. Parallel to the development of traditional molecules such as nucleoside analogues, whose effectiveness is well demonstrated, pharmaceutical industry is now turning to new solutions such as antiviral peptides, which constitute a new exploration field in therapy. The recent progress in disciplines such as genomics, proteomics and structural biology have improved our fundamental understanding of the viral world. These advances can be used to efficiently create new drugs more selective and more effective. Identification and development of these molecules require the use of newer techniques such as high-throughput screening of combinatorial compound libraries and the use of new bioinformatics tools. This review aims to present some recent methods for the development of antiviral molecules.
📜 SIMILAR VOLUMES
Abstraet--A matrix formalism, which rationalizes use of atomic spectroscopic data in LCAO molecular orbitaltheory for conjugated systems, is described. SCF molecular orbitals are determined by a modified matrix density method applicable to closed shells and open shells systems. The method is particu