Synthesis of mannich bases of arylidenep
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Catherine Rubat; Pascal Coudert; Eliane Albuisson; Janine Bastide; Joele Couquel
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Article
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1992
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John Wiley and Sons
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English
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A series of 5-arylidenepyridazin-3-ones substituted in the 2-position by an arylpiperazinoalkyl moiety (2-16) was synthesized and evaluated for analgesic activity. In the phenylbenzoquinone-induced writhing test, Mannich bases 2-14 were the most active compounds (6.1 < or = ED50 < or = 43.0 mg/kg, o