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Notch1 activation promotes renal cell carcinoma growth via PI3K/Akt signaling

✍ Scribed by Le Xu; Yu Zhu; Jiejie Xu; Kerong Wu; Jinfeng Li; Wenping Xu; Haiou Liu; Shanshan Wang; Hankun Yin; Lin Chen; Guomin Wang; Zongming Lin

Book ID
114703266
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
758 KB
Volume
103
Category
Article
ISSN
1347-9032

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## Abstract Activated phosphoinositide 3‐kinase (PI3K) and its downstream target Akt/PKB are important signaling molecules and key survival factors involved in the control of cell proliferation, apoptosis and oncogenesis. We investigated the role of the PI3K‐Akt signaling pathway in the invasion of