Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus

Altered T cell differentiation and Notch

Altered T cell differentiation and Notch signaling induced by the ectopic expression of keratin K10 in the epithelial cells of the thymus

✍ Mirentxu Santos; Paula Río; Sergio Ruiz; Jesús Martínez-Palacio; Carmen Segrelle 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 971 KB

Transgenic mice expressing hK10 under the keratin K5 promoter display several alterations in the epidermis including decreased cell proliferation, and reduced susceptibility to tumor development. Given that K5 promoter is also active in the epithelial cells of the thymus, we explored the possible al

T-cell priming by type-1and type-2 polar

T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal

✍ Pawel Kaliński; Catharien M.U Hilkens; Eddy A Wierenga; Martien L Kapsenberg 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 223 KB

fficient responses to different types of pathogens require different mechanisms of immunity. Similarly, for optimal effectiveness and minimal damage to local tissues, the character of the response must be modified to suit particular body compartments. The selection of effector immune functions is co

Early afferent signaling in the outer pl

Early afferent signaling in the outer plexiform layer regulates development of horizontal cell morphology

✍ Mary E. Raven; Noelle C. Orton; Hadi Nassar; Gary A. Williams; William K. Stell; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 464 KB

## Abstract The pedicles of cone photoreceptors, labeled with an antibody to mouse cone arrestin (blue), stratify in the outer plexiform layer, where they form synapses with the dendrites of horizontal and bipolar cells. Those synaptic sites are evidenced by the co‐localization of the synaptic ribb

Early afferent signaling in the outer pl

Early afferent signaling in the outer plexiform layer regulates development of horizontal cell morphology

✍ Mary E. Raven; Noelle C. Orton; Hadi Nassar; Gary A. Williams; William K. Stell; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 463 KB

## Abstract The pedicles of cone photoreceptors, labeled with an antibody to mouse cone arrestin (blue), stratify in the outer plexiform layer, where they form synapses with the dendrites of horizontal and bipolar cells. Those synaptic sites are evidenced by the co‐localization of the synaptic ribb

Notch1 signals through Jagged2 to regula

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud

✍ Jeffrey C. Francis; Freddy Radtke; Malcolm P.O. Logan 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 692 KB

Notch-1 regulates Akt signaling pathway

Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines

✍ Dongmei Guo; Jingjing Ye; Jianjian Dai; Lizhen Li; Feng Chen; Daoxin Ma; Chunyan 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 937 KB

Gain-of-function mutations in Notch-1 are common in T-cell lymphoblastic leukemia (T-ALL), making this receptor a promising target for drugs such as gamma-secretase inhibitors (GSIs). However, GSIs seem to be active in only a small fraction of T-ALL cell lines with constitutive Notch-1 activity and