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Notch Signaling Induces Apoptosis in Primary Human CD34+ Hematopoietic Progenitor Cells

✍ Scribed by Nicholas Chadwick; Maria Cristina Nostro; Martin Baron; Rachel Mottram; Gerard Brady; Anne-Marie Buckle

Book ID: 111843631
Publisher: AlphaMed Press
Year: 2006
Tongue: English
Weight: 392 KB
Volume: 25
Category: Article
ISSN: 1066-5099
DOI: 10.1634/stemcells.2005-0303

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## Abstract ## Background Conventional gene‐therapy applications of hematopoietic stem cells (HSCs) involve purification of CD34+ progenitor cells from the mobilized peripheral blood, __ex vivo__ transduction of the gene of interest into them, and reinfusion of the transduced CD34+ progenitor cell