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Retinoic acid induces apoptosis of human CD34+ hematopoietic progenitor cells: Involvement of retinoic acid receptors and retinoid X receptors depends on lineage commitment of the hematopoietic progenitor cells

✍ Scribed by Dag Josefsen; Heidi Kiil Blomhoff; Jon Lømo; Anne Kirsti Blystad; Erlend B Smeland

Book ID: 114217323
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 326 KB
Volume: 27
Category: Article
ISSN: 0301-472X
DOI: 10.1016/s0301-472x(98)00073-3

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## Abstract __N__‐(4‐hydroxyphenyl)retinamide (4HPR, fenretinide), a retinoic acid (RA) derivative and a potential cancer preventive agent, is known to exert its chemotherapeutic effects in cancer cells through induction of apoptosis. Earlier work from our laboratory has shown that relatively low c