## Abstract Notch signaling pathway, originally discovered in Drosophila, impinges on a wide array of cellular processes including cell proliferation, cell differentiation, and cell apoptosis. Recent accumulating evidences implicated the important roles of Notch signal pathway in different aspects
Notch as a molecular switch in neural stem cells
β Scribed by Zhi-Dong Zhou; Udhaya Kumari; Zhi-Cheng Xiao; Eng-King Tan
- Book ID
- 102282733
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 141 KB
- Volume
- 62
- Category
- Article
- ISSN
- 1521-6543
- DOI
- 10.1002/iub.372
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β¦ Synopsis
Abstract
Notch as a Molecular Switch in Neural Stem Cells by ZhiβDong Zhou, Udhaya Kumari, ZhiβCheng Xiao, and EngβKing Tan, pp. 618β623.
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Neural stem cells (NSC) are a valuable model system for understanding the intrinsic and extrinsic controls for self-renewal and differentiation choice. They also offer a platform for drug screening and neurotoxicity studies, and hold promise for cell replacement therapies for the treatment of neurod
## Abstract In recent years several reports have claimed to demonstrate transβdifferentiation, namely that stem cells have been derived from a given tissue and have differentiated into phenotypes characteristic of different tissues following transplantation or in vitro treatment. For example, the m