Notch as a molecular switch in neural stem cells

✍ Scribed by Zhi-Dong Zhou; Udhaya Kumari; Zhi-Cheng Xiao; Eng-King Tan

• Book ID: 102281823
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 389 KB
• Volume: 62
• Category: Article
• ISSN: 1521-6543
• DOI: 10.1002/iub.362

✦ Synopsis

Abstract

Notch signaling pathway, originally discovered in Drosophila, impinges on a wide array of cellular processes including cell proliferation, cell differentiation, and cell apoptosis. Recent accumulating evidences implicated the important roles of Notch signal pathway in different aspects of stem cell biology of neural stem cell (NSC). In vivo and in vitro studies illustrated that Notch signal pathway could promote gliogenesis, inhibit premature neurogenesis, and be involved in self‐renew of NSC. This short review summarizes the roles of the Notch signaling pathway on gliogenesis, neurogenesis, and self‐renew of NSC and their underlying molecular mechanisms. © 2010 IUBMB IUBMB Life, 62(8): 618–623, 2010.