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Notch-1 activation by familial Alzheimer's disease (FAD)-linked mutant forms of presenilin-1

✍ Scribed by Mitsunari Nakajima; Takahiko Shimizu; Takuji Shirasawa

Book ID
101337270
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
296 KB
Volume
62
Category
Article
ISSN
0360-4012

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πŸ“œ SIMILAR VOLUMES

Human presenilin-1, but not familial Alz
Human presenilin-1, but not familial Alzheimer’s disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing
✍ Ralf Baumeister; Uwe Leimer; Inge Zweckbronner; Constanze Jakubek; JΓΌrgen GrΓΌn πŸ“‚ Article πŸ“… 1997 πŸ› Blackwell Publishing 🌐 English βš– 506 KB

The majority of cases with familial Alzheimer’s disease (FAD) are linked to mutations of the presenilin (PS) genes. These genes show considerable sequence similarity to the __sel‐12__ gene of __Caenorhabditis elegans__, which has been postulated to function in the facilitated signalling by __lin‐12_