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Normoxic induction of cerebral HIF-1α by acetazolamide in rats: Role of acidosis

✍ Scribed by Jiajun Xu; Zhaoyun Peng; Runping Li; Tonghai Dou; Weigang Xu; Guojun Gu; Yun Liu; Zhimin Kang; Hengyi Tao; John H. Zhang; Robert P. Ostrowski; Jian Lu; Xuejun Sun

Book ID: 116771111
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 471 KB
Volume: 451
Category: Article
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2009.01.008

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## Abstract Large osteoclasts (10+ nuclei), predominant in rheumatoid arthritis and periodontal disease, have higher expression of proteases and activating receptors and also have increased resorptive activity when compared to small (2–5 nuclei) osteoclasts. We hypothesized that large and small ost