Normalization of serum lactic dehydrogenase in β-thalassemia patients following bone marrow transplantation

✍ Scribed by Toren, Amos; Or, Reuven; Kapelushnik, Joseph; Chividalli, Gabriel; Aku, Memet; Slavin, Shimon; Nagler, Arnon

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 153 KB
• Volume: 51
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/(sici)1096-8652(199602)51:2<166::aid-ajh13>3.0.co;2-g

✦ Synopsis

Serum lactic dehydrogenase (LDH) levels are mildly elevated In p-thalassemia major due to Ineffective erythropolesls. We reviewed the charts of 15 consecutive thalassemlc children who underwent allogeneic, 1-cell-depleted bone marrow transplantation (BMT) in our department during the last 3 years. Eleven patients had successful engraftment and are alive and well without evidence of disease, according to physical examinations, blood counts, and polymerase chain reaction (PCR) tests, with a median follow-up of 2 years. Two patients died due to transplantation-related complications, and two rejected the graft and received their backup autologous marrow. The LDH levels in the transplanted patients gradually decreased from an average of 952 f 155 IUIL 10 days pre-transplant (N = 300-620) to 426 * 56 IUIL at the day of transplantation, and stayed at approximately the same level post-transplant (489 f 55 IUIL). By contrast, the LDH levels reverted to the pre-transplant value in those patients who rejected their marrow. The significance of this clinical observation for the pathophyslologic mechanism of lntramedullary hemolysis and Ineffective erythropolesls in pthalassemla major is discussed.