Normal urinary excretion of catecholamine catabolites in children with retinoblastoma
β Scribed by Orlowski, James P. ;Levin, Howard S. ;Price, Ronald L. ;Dyment, Paul G.
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 336 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0098-1532
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β¦ Synopsis
Urinary catecholamine catabolites, homovanillic acid, vanillylmandelic acid, total metanephrines, and total catecholamines were assayed in 12 patients with newly diagnosed retinoblastoma prior to surgery and treatment. These values were within normal limits for the ages of all 12 patients, including one with metastases to brain, liver, lymph nodes, and bone marrow. The predictive value and efficiency of these tests in the diagnosis of retinoblastoma are insufficient to warrant their continued use on a routine basis.
π SIMILAR VOLUMES
Neuroblastomas are malignant tumors derived embryonically from the neural crest. Biological diagnosis relies on assay of urinary excretion of homovanillic acid (HVA), vanillylmandelic acid (VMA), and dopamine (DA). Spontaneous regression of these neoplasms has been reported by numerous investigators
R3ISTKONG and co-workers2 in 1956 first de-A scribed a metabolite of norepinephrine in human urine that Armstrong et al.3 in 1957 idcntified a5 3-r1iethoxy-4-Lrvdroxyluandelic acid, or vanilmandelic acid (VMA). 'This phenolic ;Icid was soon confirmed to be the chief bie;iktlown product of norepineph