We have developed a sensitive ELISA using MAb 4D3 for the detection of a novel epitope on Small Intestinal Mucin Antigen (SIMA) and report here that SlMA is present in the serum of patients with colorectal cancer. SlMA has been shown to occur in tissue from a high proportion of patients with colorec
✦ LIBER ✦
Normal Salivary Mucin Contains the Gastrointestinal Cancer-Associated Antigen Detected by Monoclonal Antibody 19–9 in the Serum Mucin of Patients
✍ Scribed by Manfred Brockhaus; Marie Wysocka; John L. Magnani; Zenon Steplewski; Hilary Koprowski; Victor Ginsburg
- Book ID
- 115108860
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 304 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0042-9007
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The cancer-associated epitope defined by the monoclonal antibody (MAb) 9H8 was shown to be closely related to the T antigen (Thornsen-Friedenreich antigen) by its sensitivity to 0-glycanase treatment of a mucin glycopeptide known to express this epitope. The reactivity with this glycopeptide increas