✦ LIBER ✦

Normal neuropathological findings after neuroleptic malignant syndrome

✍ Scribed by Hannu J. Koponen; Ulla Lepola; Esa Leinonen; Leo Paljärvi

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 235 KB
Volume: 8
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470080308

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✦ Synopsis

Neuroleptic malignant syndrome (NMS) is a rare, life-threatening complication of antipsychotic drug treatment. Its pathophysiology is controversial, and the same is true for the findings in post-mortem studies on central nervous system pathology. In this report we present a patient who died two and a half months after suffering NMS. The findings in a thorough neuropathological examination were normal suggesting that the postulated dopamine receptor blockade in NMS is not associated with a structural central nervous system damage.

KEY worms-Adverse drug reaction, antipsychotic drugs, neuroleptic malignant syndrome, neuropathology.

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