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Norepinephrine promotes long-term potentiation in the adult rat hippocampus in vitro

✍ Scribed by Yukitoshi Izumi; Charles F. Zorumski

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 74 KB
Volume: 31
Category: Article
ISSN: 0887-4476
DOI: 10.1002/(sici)1098-2396(19990301)31:3<196::aid-syn4>3.0.co;2-k

No coin nor oath required. For personal study only.

✦ Synopsis

We previously found a reduction in the ability of a single 100 Hz ϫ 1 sec tetanus to induce long-term potentiation (LTP) in the CAl region of hippocampal slices prepared from adult animals. To determine whether this reduction in LTP generation results from changes in neuromodulator function, we examined the ability of several neuromodulators to promote LTP in slices prepared from mature rats. Although acetylcholine, N-methyl-D-aspartate, and an agonist at metabotropic glutamate receptors failed to promote LTP, administration of norepinephrine allowed robust LTP. The effects of norepinephrine were mimicked by an ␣1-adrenergic agonist and were blocked by an ␣1-receptor antagonist. ␤-adrenergic agonists and antagonists were ineffective. These results suggest that norepinephrine acting via ␣1-adrenoceptors may be an important cofactor in promoting lasting synaptic plasticity in the adult central nervous system and that changes in adrenergic function may contribute to maturation-or aging-associated changes in memory function.

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