Changes in synaptic structure have been reported following the induction of long-term potentiation (LTP). The structure of synapses during the intermediate maintenance of LTP has yet to be fully characterized in chronically implanted freely moving animals. The present study examined synapses in the
Sequential changes in the synaptic structural profile following long-term potentiation in the rat dentate gyrus: III. Long-term maintenance phase
โ Scribed by Andrew C.W. Weeks; Tammy L. Ivanco; Janelle C. Leboutillier; Ronald J. Racine; Ted L. Petit
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 173 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0887-4476
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Long-term potentiation (LTP), one of the most compelling models of learning and memory, has been associated with changes in synaptic morphology. In this study, LTP was induced and animals were sacrificed 1 h after the stimulation of the LTP group (induction / early maintenance phase). Synapses in th
We have reported that arachidonic acid and the metabotropic glutamate receptor agonist, trans-1-amino-cyclopentyl-1,3-dicarboxylate (ACPD), act in synergy to increase release of glutamate from synaptosomes prepared from rat dentate gyrus. The observation that prior induction of LTP in perforant path