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Norepinephrine decreases EGF binding in primary rat hepatocyte cultures

✍ Scribed by Jennifer L. Cruise; Susanna Cotecchia; George Michalopoulos

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 604 KB
Volume: 127
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041270106

No coin nor oath required. For personal study only.

✦ Synopsis

Norepinephrine (NE) produced a dose-dependent inhibition of 1251-epidermal growth factor (EGF) binding to adult rat hepatocytes in primary culture. This effect was maximal after 1 hr of incubation with NE and could be blocked by the presence of an cq-specific adrenergic receptor antagonist. The inhibition of binding correlates with the ability of NE to enhance hepatocyte DNA synthesis in the presence of EGF and appears to be mediated by a reduction in EGF receptor number, without a significant change in receptor affinity.

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