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Nootropic effects of ACE inhibitors in mice

✍ Scribed by C. Mondadori; P. Etienne


Publisher
Springer
Year
1990
Tongue
English
Weight
721 KB
Volume
100
Category
Article
ISSN
0033-3158

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Scopolamine (3 mg/kg IP) given before an acquisition trial, reduced the retention of a one-trial passive avoidance "step through" response in mice. A single administration of cholinergic agonists such as oxotremorine, BM-5, or arecoline, antagonized this amnesic effect of scopolamine. A significant